Role of Mitochondrial Dynamics and Autophagy in Removal of Helix-Distorting Mitochondrial DNA Damage
نویسنده
چکیده
Role of Mitochondrial Dynamics and Autophagy in Removal of Helix-Distorting Mitochondrial DNA Damage by Amanda Smith Bess Environment Duke University Date:_______________________ Approved: ___________________________ Joel N. Meyer, Supervisor ___________________________ William C. Copeland ___________________________ Richard T. Di Giulio ___________________________ David E. Hinton An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Environment in the Graduate School of Duke University 2012 Copyright by Amanda Smith Bess 2012
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Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans
Mitochondria lack the ability to repair certain helix-distorting lesions that are induced at high levels in mitochondrial DNA (mtDNA) by important environmental genotoxins and endogenous metabolites. These lesions are irreparable and persistent in the short term, but their long-term fate is unknown. We report that removal of such mtDNA damage is detectable by 48 h in Caenorhabditis elegans, and...
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